منابع مشابه
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.
Homology searches and amino acid alignments, using the Streptomyces R61 DD-peptidase/penicillin-binding protein as reference, have been applied to the beta-lactamases of classes A and C, the Oxa-2 beta-lactamase (considered as the first known member of an additional class D), the low-Mr DD-peptidases/penicillin-binding proteins (protein no. 5 of Escherichia coli and Bacillus subtilis) and penic...
متن کاملThe active centres in penicillin-sensitive enzymes.
The interaction between beta-lactam antibiotics and the penicillin-sensitive enzymes is a multiple-step process. Binding of the beta-lactam ring of the penam (or 3-cepham) nucleus occurs at binding site no. 1. Interaction between the N-14 substituent of the bound molecule and binding site no. 2 induces changes in binding site no. 1. In turn, the catalytic site thus created increases the chemica...
متن کاملInteraction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.
INTRODUCTION ........................................................ 291 General ............... ......................................... 291 Cell Waill Structure and Synthesis ....................... ........................ 292 Identification of the Target of Penicillin Action .......... ........................ 293 PENICILLIN-BINDING COMPONENTS .............. .......................... 296...
متن کاملBENZYL PENICILLIN, BENZYL PENICILLIN India, BENZYL PENICILLIN manufacturers India
PENICILLIN India, BENZYL PENICILLIN side effects, BENZYL PENICILLIN use, BENZYL PENICILLIN overdose, BENZYL PENICILLIN drug, BENZYL PENICILLIN composition, BENZYL PENICILLIN Manufacturing, Pharmaceutical manufacturers, BENZYL PENICILLIN contains, BENZYL PENICILLIN Manufacturing, BENZYL PENICILLIN Pharmaceutical manufacturers, BENZYL PENICILLIN side effects, BENZYL PENICILLIN use BENZYL PENICILL...
متن کاملReactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
Beta-lactams exert their antibiotic action through their inhibition of bacterial DD-peptidases (penicillin-binding proteins). Bacteria, in general, carry several such enzymes localized on the outside of their cell membrane to catalyze the final step in cell wall (peptidoglycan) synthesis. They have been classified into two major groups, one of high molecular weight, the other of low. Members of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 1988
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst0160934